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Science for All Seasons - Proteomics: Translating the code of life
Proteomics: Translating the code of life
The genome encodes the basic blueprints and switches underlying everything a cell does, but it's the proteome — the cell's collection of proteins — that does the work of carrying signals, turning circuits on and off, processing energy, and more. How do researchers study the proteome, and how does that knowledge translate into new approaches to treating disease? Research scientist Namrata Udeshi and physician-scientist Michael Gillette will take us on a tour of the proteome and some of the opportunities that the science of proteomics presents for advancing human health.

Namrata Udeshi
Namrata Udeshi is the associate director of the Proteomics Platform at the Broad Institute of MIT and Harvard. Her focus over the past >15 years has been the development of novel state-of-the-art mass spectrometry-driven technology for analysis of protein expression, interaction, and post-translational modifications. Udeshi performs unbiased analyses at nearly whole proteome coverage to decipher signaling pathways and identify key regulatory proteins in biological systems that are associated with physiological disease or drug perturbation phenotypes. She has also developed methods that have been critical to understanding altered protein modification in cancer.


Michael Gillette
Mike Gillette is a senior group leader in proteomics and biomarker discovery at the Broad Institute of MIT and Harvard. He is also a pulmonary and critical care medicine attending and associate physician at the Massachusetts General Hospital and an assistant professor of medicine at Harvard Medical School. Gillette has a particular interest in clinical proteomics and biomarker development, including breast and ovarian cancer proteomic biomarker discovery and molecular characterization of infectious diseases of high international health import, including pediatric febrile illness and tuberculosis.

Apr 6, 2021 05:00 PM in Eastern Time (US and Canada)

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